Exercise capacity in the Fontan circulation

被引：69

作者：

Goldberg, David J. ^{[1
,2
]}

Avitabile, Catherine M. ^{[1
]}

McBride, Michael G. ^{[1
]}

Paridon, Stephen M. ^{[1
,2
]}

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Cardiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

来源：

CARDIOLOGY IN THE YOUNG | 2013年 / 23卷 / 06期

关键词：

Congenital heart disease; exercise; Fontan; PRESERVED EJECTION FRACTION; HEART-FAILURE; CARDIORESPIRATORY RESPONSE; HEMODYNAMIC-RESPONSE; OPERATION; BOSENTAN; DETERMINANTS; PERFORMANCE; SILDENAFIL; CHILDREN;

D O I：

10.1017/S1047951113001649

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Fontan operation can create a stable circulation from childhood through early adulthood. However, the absence of a sub-pulmonary pumping chamber leads to a physiology in which exercise capacity is limited and decreases with age starting in adolescence. The limitation in exercise capacity is more pronounced at peak levels of exercise, but is still present during more modest levels of activity. The underlying causes of exercise impairment relate to both central cardiovascular factors (oxygen delivery) and peripheral factors (oxygen extraction). Interventions to improve cardiac preload and to improve lean muscle mass may help to improve exercise capacity and, perhaps, will alter the "natural history'' of the progressive decline.

引用

页码：824 / 830

页数：7