Functional organization of intrinsic and feedback presynaptic inputs in the primary visual cortex

被引:18
作者
Zhang, Qing-fang [1 ]
Li, Hao [1 ]
Chen, Ming [1 ]
Guo, Aike [1 ,2 ,3 ]
Wen, Yunqing [1 ]
Poo, Mu-ming [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci,State Key Lab Neurosci, Shanghai 200031, Peoples R China
[2] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
基金
中国国家自然科学基金;
关键词
primary visual cortex; presynaptic inputs; dual-color calcium imaging; orientation selectivity; visual circuitry; ORIENTATION SELECTIVITY; PROJECTION NEURONS; CORTICAL-NEURONS; CONNECTIONS; ARRANGEMENT; SPECIFICITY; TRANSFORMATION; DOMAINS; CELLS; V1;
D O I
10.1073/pnas.1719711115
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In the primary visual cortex (V1) of many mammalian species, neurons are spatially organized according to their preferred orientation into a highly ordered map. However, whether and how the various presynaptic inputs to V1 neurons are organized relative to the neuronal orientation map remain unclear. To address this issue, we constructed genetically encoded calcium indicators targeting axon boutons in two colors and used them to map the organization of axon boutons of V1 intrinsic and V2-V1 feedback projections in tree shrews. Both connections are spatially organized into maps according to the preferred orientations of axon boutons. Dual-color calcium imaging showed that V1 intrinsic inputs are precisely aligned to the orientation map of V1 cell bodies, while the V2-V1 feedback projections are aligned to the V1 map with less accuracy. Nonselective integration of intrinsic presynaptic inputs around the dendritic tree is sufficient to reproduce cell body orientation preference. These results indicate that a precisely aligned map of intrinsic inputs could reinforce the neuronal map in V1, a principle that may be prevalent for brain areas with function maps.
引用
收藏
页码:E5174 / E5182
页数:9
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