Thymine Modified Amphiphilic Biodegradable Copolymers for Photo-Cross-Linked Micelles as Stable Drug Carriers

被引：8
|
作者：
Kuang, Huihui [1 ,2 ]
He, Hongyan [1 ,2 ]
Hou, Jie [3 ]
Xie, Zhigang [1 ]
Jing, Xiabin [1 ]
Huang, Yubin [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
[3] Jia Mu Si Univ, Hosp 1, Jiamusi 154002, Peoples R China
来源：
MACROMOLECULAR BIOSCIENCE | 2013年 / 13卷 / 11期
基金：
中国国家自然科学基金;
关键词：
amphiphilic copolymers; degradable; drug delivery; photo-cross-linking; thymine; DELIVERY; LINKING; POLYMERS; SYSTEM; NANOPARTICLES; DERIVATIVES; PACLITAXEL;
D O I：
10.1002/mabi.201300254
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A photo-cross-linked micelle is synthesized via photodimerization of thymine moieties fabricated from amphiphilic block copolymers (mPEG-b-P(LA-co-MPT). The crosslinking behavior is monitored by UV-Vis spectra and H-1 NMR. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) showed that cross-linked micelles had smaller sizes than their uncross-linked precursors. In vitro studies reveal that cross-linking of the micelle cores results in a slow drug release and faster cellular uptake in comparison with uncross-linked ones in MCF-7 and Hela cells. Moreover, the paclitaxel (PTX)-loaded core-cross-linked micelles exhibit similar anticancer efficacy as free PTX. This work provides a convenient tool for designing a more stable structure in the blood circulation to realize a controlled drug delivery.
引用
收藏
页码：1593 / 1600
页数：8
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