X-ray structure analysis of a solid solution of milbemycins A3 and A4

被引：4

作者：

Bizdena, E. ^{[1
]}

Belyakov, S. ^{[2
]}

Jure, M. ^{[1
]}

Grinsteine, I. ^{[1
,3
]}

Kumpins, V. ^{[1
]}

Turks, M. ^{[1
]}

机构：

[1] Riga Tech Univ, Fac Mat Sci & Appl Chem, LV-1007 Riga, Latvia

[2] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

[3] PharmIdea Ltd, LV-2114 Olaine, Riga District, Latvia

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 20期

关键词：

milbemycin A(3); milbemycin A(4); X-ray structure; solid solution;

D O I：

10.1080/14786419.2013.791820

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Milbemycins A(3) and A(4) are pharmaceutically and agriculturally useful macrolides isolated from Streptomyces species. The molecular structures of the title compounds were unambiguously established by a single crystal X-ray analysis of the solid solution of both compounds. The crystals present trigonal system, space group P3(2) with Z=3, unit cell dimensions: a=12.2211(4), c=17.5372(7)angstrom; V=2268.4(1)angstrom(3), =0.082mm(-1); d=1.183gcm(-3). An interesting system of intramolecular hydrogen bonds and weak intermolecular CH...O type hydrogen bond was observed in the solid state.

引用

页码：1936 / 1939

页数：4

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