Spectral Context Affects Temporal Processing in Awake Auditory Cortex

被引:21
作者
Malone, Brian J. [1 ]
Beitel, Ralph E. [1 ]
Vollmer, Maike [2 ]
Heiser, Marc A. [3 ]
Schreiner, Christoph E. [4 ]
机构
[1] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
[2] Univ Hosp Wuerzburg, Comprehens Hearing Ctr, D-97080 Wurzburg, Germany
[3] Univ Calif Los Angeles, Semel Inst Neurosci & Behav, Los Angeles, CA 90024 USA
[4] UCSF Ctr Integrat Neurosci, Dept Otolaryngol Head & Neck Surg, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA
关键词
MODULATION TRANSFER-FUNCTIONS; AMPLITUDE-MODULATION; INFERIOR COLLICULUS; SPEECH RECOGNITION; CAT; RESPONSES; PERIODICITY; REPRESENTATION; BANDWIDTH; ENVELOPE;
D O I
10.1523/JNEUROSCI.3073-12.2013
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Amplitude modulation encoding is critical for human speech perception and complex sound processing in general. The modulation transfer function (MTF) is a staple of auditory psychophysics, and has been shown to predict speech intelligibility performance in a range of adverse listening conditions and hearing impairments, including cochlear implant-supported hearing. Although both tonal and broadband carriers have been used in psychophysical studies of modulation detection and discrimination, relatively little is known about differences in the cortical representation of such signals. We obtained MTFs in response to sinusoidal amplitude modulation (SAM) for both narrowband tonal carriers and two-octave bandwidth noise carriers in the auditory core of awake squirrel monkeys. MTFs spanning modulation frequencies from 4 to 512 Hz were obtained using 16 channel linear recording arrays sampling across all cortical laminae. Carrier frequency for tonal SAM and center frequency for noise SAM was set at the estimated BF for each penetration. Changes in carrier type affected both rate and temporal MTFs in many neurons. Using spike discrimination techniques, we found that discrimination of modulation frequency was significantly better for tonal SAM than for noise SAM, though the differences were modest at the population level. Moreover, spike trains elicited by tonal and noise SAM could be readily discriminated in most cases. Collectively, our results reveal remarkable sensitivity to the spectral content of modulated signals, and indicate substantial interdependence between temporal and spectral processing in neurons of the core auditory cortex.
引用
收藏
页码:9431 / 9450
页数:20
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