Differential expression and emerging functions of non-coding RNAs in cold adaptation

被引:11
作者
Frigault, Jacques J. [1 ]
Morin, Mathieu D. [1 ]
Morin, Pier, Jr. [1 ]
机构
[1] Univ Moncton, Dept Chem & Biochem, 18 Antonine Maillet Ave, Moncton, NB E1A 3E9, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
Mammalian hibernation; Insect cold hardiness; Cold adaptation; Non-coding RNAs; MicroRNAs; Long non-coding RNAs; 13-LINED GROUND-SQUIRRELS; MYOCYTE ENHANCER FACTOR-2; METABOLIC-RATE DEPRESSION; FREEZE-TOLERANT INSECT; GENE-EXPRESSION; LOW-TEMPERATURE; MAMMALIAN HIBERNATION; MICRORNA EXPRESSION; DNA METHYLATION; REVERSIBLE PHOSPHORYLATION;
D O I
10.1007/s00360-016-1049-2
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Several species undergo substantial physiological and biochemical changes to confront the harsh conditions associated with winter. Small mammalian hibernators and cold-hardy insects are examples of natural models of cold adaptation that have been amply explored. While the molecular picture associated with cold adaptation has started to become clearer in recent years, notably through the use of high-throughput experimental approaches, the underlying cold-associated functions attributed to several non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), remain to be better characterized. Nevertheless, key pioneering work has provided clues on the likely relevance of these molecules in cold adaptation. With an emphasis on mammalian hibernation and insect cold hardiness, this work first reviews various molecular changes documented so far in these processes. The cascades leading to miRNA and lncRNA production as well as the mechanisms of action of these non-coding RNAs are subsequently described. Finally, we present examples of differentially expressed non-coding RNAs in models of cold adaptation and elaborate on the potential significance of this modulation with respect to low-temperature adaptation.
引用
收藏
页码:19 / 28
页数:10
相关论文
共 95 条
[1]   Dynamic changes in global and gene-specific DNA methylation during hibernation in adult thirteen-lined ground squirrels, Ictidomys tridecemlineatus [J].
Alvarado, Sebastian ;
Mak, Timothy ;
Liu, Sara ;
Storey, Kenneth B. ;
Szyf, Moshe .
JOURNAL OF EXPERIMENTAL BIOLOGY, 2015, 218 (11) :1787-1795
[2]   Genes controlling the metabolic switch in hibernating mammals [J].
Andrews, MT .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2004, 32 :1021-1024
[3]   A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice [J].
Aravin, Alexei A. ;
Sachidanandam, Ravi ;
Bourc'his, Deborah ;
Schaefer, Christopher ;
Pezic, Dubravka ;
Toth, Katalin Fejes ;
Bestor, Timothy ;
Hannon, Gregory J. .
MOLECULAR CELL, 2008, 31 (06) :785-799
[4]   circRNA Biogenesis Competes with Pre-mRNA Splicing [J].
Ashwal-Fluss, Reut ;
Meyer, Markus ;
Pamudurti, Nagarjuna Reddy ;
Ivanov, Andranik ;
Bartok, Osnat ;
Hanan, Mor ;
Evantal, Naveh ;
Memczak, Sebastian ;
Rajewsky, Nikolaus ;
Kadener, Sebastian .
MOLECULAR CELL, 2014, 56 (01) :55-66
[5]   Insect overwintering in a changing climate [J].
Bale, J. S. ;
Hayward, S. A. L. .
JOURNAL OF EXPERIMENTAL BIOLOGY, 2010, 213 (06) :980-994
[6]   Insects and low temperatures: from molecular biology to distributions and abundance [J].
Bale, JS .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2002, 357 (1423) :849-861
[7]   Intermediate activity of midge antifreeze protein is due to a tyrosine-rich ice-binding site and atypical ice plane affinity [J].
Basu, Koli ;
Wasserman, Samantha S. ;
Jeronimo, Paul S. ;
Graham, Laurie A. ;
Davies, Peter L. .
FEBS JOURNAL, 2016, 283 (08) :1504-1515
[8]   Regulation of liver glutamate dehydrogenase by reversible phosphorylation in a hibernating mammal [J].
Bell, Ryan A. V. ;
Storey, Kenneth B. .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2010, 157 (03) :310-316
[9]   The mitochondrial lncRNA ASncmtRNA-2 is induced in aging and replicative senescence in Endothelial Cells [J].
Bianchessi, Valentina ;
Badi, Ileana ;
Bertolotti, Matteo ;
Nigro, Patrizia ;
D'Alessandra, Yuri ;
Capogrossi, Maurizio C. ;
Zanobini, Marco ;
Pompilio, Giulio ;
Raucci, Angela ;
Lauri, Andrea .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2015, 81 :62-70
[10]   Low-temperature microRNA expression in the painted turtle, Chrysemys picta during freezing stress [J].
Biggar, Kyle K. ;
Storey, Kenneth B. .
FEBS LETTERS, 2015, 589 (23) :3665-3670