Snake venom galactoside-binding lectins: a structural and functional overview

被引:34
作者
Sartim, Marco A. [1 ]
Sampaio, Suely V. [1 ]
机构
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
Snake venom; C-type lectin; Galactoside-binding protein; Carbohydrate recognition domain; Glycoconjugates; Inflammatory response; Antitumor activity; Bactericidal activity; Mitogenic activity; Platelet aggregation; C-TYPE LECTIN; BOTHROPS-JARARACUSSU VENOM; AMINO-ACID-SEQUENCE; NEUTROPHIL CHEMOTACTIC FACTOR; LACHESIS-MUTA; TRIMERESURUS-OKINAVENSIS; SARCOPLASMIC-RETICULUM; QUATERNARY STRUCTURE; ACUTE-INFLAMMATION; BITIS ARIETANS;
D O I
10.1186/s40409-015-0038-3
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Snake venom galactoside-binding lectins (SVgalLs) comprise a class of toxins capable of recognizing and interacting with terminal galactoside residues of glycans. In the past 35 years, since the first report on the purification of thrombolectin from Bothrops atrox snake venom, several SVgalLs from Viperidae and Elapidae snake families have been described, as has progressive improvement in the investigation of structural/functional aspects of these lectins. Moreover, the advances of techniques applied in protein-carbohydrate recognition have provided important approaches in order to screen for possible biological targets. The present review describes the efforts over the past 35 years to elucidate SVgalLs, highlighting their structure and carbohydrate recognition function involved in envenomation pathophysiology and potential biomedical applications.
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页数:11
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