Volume stabilization in human erythrocytes:: combined effects of Ca2+-dependent potassium channels and adenylate metabolism

被引：11
|
作者：
Martinov, MV [1 ]
Vitvitsky, VM [1 ]
Ataullakhanov, FI [1 ]
机构：
[1] Natl Res Ctr Hematol, Moscow 125167, Russia
来源：
BIOPHYSICAL CHEMISTRY | 1999年 / 80卷 / 03期
关键词：
volume regulation; human erythrocytes; adenylate metabolism; Ca2+-dependent K+ channels; Na+/K+ ATPase;
D O I：
10.1016/S0301-4622(99)00079-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A mathematical model describing the possible role of Ca2+-dependent K+ channels and adenylate metabolism in volume stabilization of human erythrocytes was developed. The model-predicts that the red blood cell volume can be stabilized either dynamically or stationary over a broad range of cell membrane permeabilities to cations. The dynamic stabilization results from the operation of Ca2+-dependent potassium channels. The erythrocyte volume changes less than 10% if the membrane permeability changes abruptly to a value in the range from half to sevenfold higher than the normal one. The stationary stabilization is achieved via controlling the adenylate metabolism. The stationary value of cell volume changes less than 10% when the membrane permeability varies from half the normal value to 15-fold higher than the normal value. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：199 / 215
页数：17
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