Arginine vasopressin significantly increases the rate of successful organ procurement in potential donors

被引:46
作者
Plurad, David S. [1 ]
Bricker, Scott [1 ]
Neville, Angela [1 ]
Bongard, Frederic [1 ]
Putnam, Brant [1 ]
机构
[1] Harbor UCLA Med Ctr, Div Trauma Acute Care Surg & Surg Crit Care, Torrance, CA 90509 USA
关键词
Arginine vasopressin; Transplantation; Organ donation; Hormone replacement therapy; Brain death; Organ procurement; Thyroxine; Traumatic brain injury; Trauma; MANAGEMENT; DONATION; IMPACT; DEFICIENCY; CRITERIA;
D O I
10.1016/j.amjsurg.2012.05.011
中图分类号
R61 [外科手术学];
学科分类号
摘要
BACKGROUND: Hormone replacement therapy increases the number and quality of grafts recovered from brain-dead organ donors. Arginine vasopressin (AVP) has also been shown to have beneficial effects. The aim of this study was to determine the effect of AVP on recovery rates. METHODS: The Organ Procurement and Transplantation Network database was used. Donors treated with hormone replacement therapy and vasopressor agents who were successfully procured between January 1, 2009, and June 30, 2011, were studied. AVP-positive and AVP-negative donors were compared. The primary study end point was the rate of high-yield procurement (>= 4 organs). RESULTS: A total of 10,431 donors were included. AVP was infused in 7,873 (75.5%) and was associated with an increased rate of high-yield procurement (50.5% vs 35.6%, P < .001). There was less overall graft refusal due to poor function (38.9% vs 45.6%, P < .001). AVP independently predicted high yield procurement. CONCLUSIONS: The use of AVP with hormone replacement therapy is independently associated with an increased rate of organ recovery. This strategy should be universally adopted in the management of donors progressing to neurologic death. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:856 / 860
页数:5
相关论文
共 28 条
[1]   Relationship of Hormonal Resuscitation Therapy and Central Venous Pressure on Increasing Organs for Transplant [J].
Abdelnour, Tina ;
Rieke, Steve .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2009, 28 (05) :480-485
[2]   Report of a national conference on donation after cardiac death [J].
Bernat, JL ;
D'Alessandro, AM ;
Port, FK ;
Bleck, TP ;
Heard, SO ;
Medina, J ;
Rosenbaum, SH ;
DeVita, MA ;
Gaston, RS ;
Merion, RM ;
Barr, ML ;
Marks, WH ;
Nathan, H ;
O'Connor, K ;
Rudow, DL ;
Leichtman, AB ;
Schwab, P ;
Ascher, NL ;
Metzger, RA ;
Mc Bride, V ;
Graham, W ;
Wagner, D ;
Warren, J ;
Delmonico, FL .
AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (02) :281-291
[3]   Impact of terlipressin on renal graft function [J].
Blasco, Valery ;
Leone, Marc ;
Geissler, Alain ;
Antonini, Francois ;
Albanese, Jacques ;
Martin, Claude .
SHOCK, 2008, 29 (06) :667-669
[4]   Bacterial- and fungal-positive cultures in organ donors: Clinical impact in liver transplantation [J].
Cerutti, Elisabetta ;
Stratta, Chiara ;
Romagnoli, Renato ;
Serra, Roberto ;
Lepore, Mirella ;
Fop, Fabrizio ;
Mascia, Luciana ;
Lupo, Francesco ;
Franchello, Alessandro ;
Panio, Angelo ;
Salizzoni, Mauro .
LIVER TRANSPLANTATION, 2006, 12 (08) :1253-1259
[5]  
Chen JM, 1999, CIRCULATION, V100, P244
[6]   Impact of Low-dose Vasopressin on Trauma Outcome: Prospective Randomized Study [J].
Cohn, Stephen M. ;
McCarthy, Janet ;
Stewart, Ronald M. ;
Jonas, Rachelle B. ;
Dent, Daniel L. ;
Michalek, Joel E. .
WORLD JOURNAL OF SURGERY, 2011, 35 (02) :430-439
[7]  
DuBose Joseph, 2008, J Intensive Care Med, V23, P367, DOI 10.1177/0885066608324208
[8]   Results With Expanded Donor Acceptance Criteria in Heart Transplantation [J].
Forni, A. ;
Luciani, G. B. ;
Chiominto, B. ;
Pizzuti, M. ;
Mazzucco, A. ;
Faggian, G. .
TRANSPLANTATION PROCEEDINGS, 2011, 43 (04) :953-959
[9]   Physiology of vasopressin relevant to management of septic shock [J].
Holmes, CL ;
Patel, BM ;
Russell, JA ;
Walley, KR .
CHEST, 2001, 120 (03) :989-1002
[10]   ANTERIOR AND POSTERIOR PITUITARY-FUNCTION IN BRAIN-STEM-DEAD DONORS - A POSSIBLE ROLE FOR HORMONAL REPLACEMENT THERAPY [J].
HOWLETT, TA ;
KEOGH, AM ;
PERRY, L ;
TOUZEL, R ;
REES, LH .
TRANSPLANTATION, 1989, 47 (05) :828-834