Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine

被引：18
|
作者：
Ohri, S [1 ]
Sharma, D [1 ]
Dixit, A [1 ]
机构：
[1] Jawaharlal Nehru Univ, Ctr Biotechnol, Gene Regulat Lab, New Delhi 110067, India
来源：
CELL BIOLOGY INTERNATIONAL | 2002年 / 26卷 / 02期
关键词：
regenerating liver; MPG; c-myc; c-fos;
D O I：
10.1006/cbir.2001.0825
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Expression of the two proto-oncogenes, c-myc and c-fos, in proliferating liver, and the modulation of their expression by 2-mercaptopropionylglycine (MPG) has been investigated. A significant increase in the expression of both c-myc and c-fos was observed, attaining a peak at 30 min, followed by a gradual decline for 8 h after partial hepatectomy. Treatment of partially hepatectomized animals with MPG resulted in a significant decrease in the expression of both genes, the decrease being more marked in c-myc mRNA levels. At later time points, there was a very small rise in the mRNA levels of these genes in MPG-treated animals but they still remained much lower than the peak levels observed in both genes 30 min after surgery. A decline in the recovery of liver weight in MPG-treated animals was also observed. (C) 2002 Elsevier Science Ltd.
引用
收藏
页码：187 / 192
页数：6
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