Precision Editing of Large Animal Genomes

被引:83
作者
Tan, Wenfang [1 ,2 ]
Carlson, Daniel F. [1 ,2 ,3 ]
Walton, Mark W. [3 ]
Fahrenkrug, Scott C. [1 ,2 ,3 ]
Hackett, Perry B. [1 ,3 ,4 ]
机构
[1] Univ Minnesota, Ctr Genome Engn, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Anim Sci, Minneapolis, MN USA
[3] Recombinetics Inc, St Paul, MN USA
[4] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN USA
来源
ADVANCES IN GENETICS, VOL 80 | 2012年 / 80卷
关键词
ZINC-FINGER NUCLEASES; GREEN FLUORESCENT PROTEIN; GERM-LINE TRANSMISSION; MEDIATED GENE-TRANSFER; DOUBLE-STRAND BREAKS; N-ACETYLGLUCOSAMINYLTRANSFERASE-III; DECAY-ACCELERATING FACTOR; TRANSGENIC DAIRY-CATTLE; DNA-BINDING SPECIFICITY; TAL EFFECTOR NUCLEASES;
D O I
10.1016/B978-0-12-404742-6.00002-8
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Transgenic animals are an important source of protein and nutrition for most humans and will play key roles in satisfying the increasing demand for food in an ever-increasing world population. The past decade has experienced a revolution in the development of methods that permit the introduction of specific alterations to complex genomes. This precision will enhance genome-based improvement of farm animals for food production. Precision genetics also will enhance the development of therapeutic biomaterials and models of human disease as resources for the development of advanced patient therapies.
引用
收藏
页码:37 / 97
页数:61
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