A supramolecular nanoprodrug based on a boronate ester linked curcumin complexing with water-soluble pillar[5]arene for synergistic chemotherapies

被引：43
作者：
Chao, Shuang [1 ]
Lv, Xiukai [1 ]
Ma, Ning [1 ]
Shen, Ziyan [1 ]
Zhang, Feiyu [1 ]
Pei, Yuxin [1 ]
Pei, Zhichao [1 ]
机构：
[1] Northwest A&F Univ, Shaanxi Key Lab Nat Prod & Chem Biol, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 62期
基金：
中国国家自然科学基金;
关键词：
RESPONSIVE DRUG-DELIVERY; PRODRUG; NANOPARTICLES; COMBINATION; SYSTEM; VESICLES;
D O I：
10.1039/d0cc04315j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A supramolecular nanoprodrug based on the host-guest complexation of water-soluble pillar[5]arene (WP5) and a boronate ester linked curcumin (Cur) was constructed, which had dual-responsiveness towards pH and GSH, allowing the drug to be selectively released in hepatoma cells.In vitrostudies revealed that the Dox-loaded WP5G-Cur nanoprodrug achieved co-delivery of Dox/Cur. The anti-cancer efficiency could be enhanced through synergistic chemotherapies of Dox/Cur.
引用
收藏
页码：8861 / 8864
页数：4
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