Collagen-grafted temperature-responsive nonwoven fabric for wound dressing

被引：24

作者：

Chen, Jyh-Ping ^{[1
]}

Lee, Wen-Li ^{[1
]}

机构：

[1] Chang Gung Univ, Dept Chem & Mat Engn, Tao Yuan 333, Taiwan

来源：

APPLIED SURFACE SCIENCE | 2008年 / 255卷 / 02期

关键词：

Collagen; Nonwoven; Wound dressing; Plasma modification;

D O I：

10.1016/j.apsusc.2008.06.111

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Polypropylene ( PP) nonwoven fabric (NWF) was modified by direct current pulsed plasma followed by grafting with acrylic acid (AAc) to improve its surface hydrophilicity and to introduce carboxylic acid group on the surface for further conjugation with bioactive collagen biomolecule. To endow temperature-responsive property, PP-g-collagen NWF was further modified with poly(N-isopropylacrylamide) ( PNIPAAm). Experimental results demonstrated that the amount of AAc and collagen grafted were 43.4 nmole/cm(2), and 35.9 mu g/cm(2), respectively. The amount of PNIPAAm immobilized was 213 mg/cm(2). The physical properties, surface chemical composition, and microstructure of the NWFs were characterized. From animal study, modified NWFs were found to promote wound healing with bigraft PP-g-collagen-g-PNIPAAm NWF showing the best performance. (c) 2008 Elsevier B. V. All rights reserved.

引用

页码：412 / 415

页数：4

共 17 条

[1] Skin substitutes: a review [J].