Exercise enhances vaccine-induced antigen-specific T cell responses

被引：29

作者：

Rogers, Connie J. ^{[2
]}

Zaharoff, David A.

Hance, Kenneth W. ^{[2
]}

Perkins, Susan N. ^{[3
]}

Hursting, Stephen D. ^{[3
,4
]}

Schlom, Jeffrey

Greiner, John W. ^{[1
]}

机构：

[1] NCI, Tumor Immunol & Biol Lab, Ctr Canc Res, Natl Inst Hlth, Bethesda, MD 20892 USA

[2] NCI, Canc Prevent Div, Canc Prevent Fellowship Program, Bethesda, MD 20892 USA

[3] Univ Texas Austin, Dept Human Ecol, Div Nutr Sci, Austin, TX 78712 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Carcinogenesis, Smithville, TX 78712 USA

来源：

VACCINE | 2008年 / 26卷 / 42期

关键词：

adaptive immunity; cytokines; cell proliferation;

D O I：

10.1016/j.vaccine.2008.07.081

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without(AL) or with access (AL+ EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4(+) T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases. Published by Elsevier Ltd.

引用

页码：5407 / 5415

页数：9

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