The application of FAIMS gas analysis in medical diagnostics

被引：71
作者：
Covington, J. A. [1 ]
van der Schee, M. P. [2 ]
Edge, A. S. L. [3 ]
Boyle, B. [3 ]
Savage, R. S. [4 ,5 ]
Arasaradnam, R. P. [6 ]
机构：
[1] Univ Warwick, Sch Engn, Coventry CV4 7AL, W Midlands, England
[2] Univ Amsterdam, Acad Med Ctr, Dept Pulm Med, NL-1105 AZ Amsterdam, Netherlands
[3] Owlstone Ltd, Cambridge CB4 0GD, England
[4] Univ Warwick, Syst Biol Ctr, Coventry CV4 7AL, W Midlands, England
[5] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England
[6] Univ Warwick, Univ Hosp Coventry & Warwick, Clin Sci Res Inst, Coventry CV2 2DX, W Midlands, England
来源：
ANALYST | 2015年 / 14卷 / 20期
基金：
英国医学研究理事会;
关键词：
ELECTRONIC NOSE; DISEASES; BREATH; TOOL;
D O I：
10.1039/c5an00868a
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
There is an ever increasing need to develop new tools to aid in the diagnosis and monitoring of human diseases. Such tools will ultimately reduce the cost of healthcare by identifying disease states more quickly and cheaply than current practices. One method showing promise is the analysis of gas-phase biomarkers from human breath, urine, sweat and stool that reflect bodily metabolism. Analysis of these volatiles by GC MS requires specialised infra-structure and staff, making it unsuitable for a clinical setting. Point of care sensor based technologies such as eNoses often suffer from stability and sensitivity issues. Field-Asymmetric Ion Mobility Spectrometry (FAIMS) has potential to fulfil this clinical need. In this paper we review the medical need, the technology, sampling methods and medical evidence thus far. We conclude with reflecting on future developmental steps necessary to bring the device into medical practice.
引用
收藏
页码：6775 / 6781
页数：7
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