Immune-mediated dormancy: an equilibrium with cancer

被引：224

作者：

Teng, Michele W. L. ^{[1
]}

Swann, Jeremy B. ^{[1
]}

Koebel, Catherine M. ^{[2
]}

Schreiber, Robert D. ^{[2
]}

Smyth, Mark J. ^{[1
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Immunol Program, Trescowthick Labs, Melbourne, Vic 8006, Australia

[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2008年 / 84卷 / 04期

关键词：

immunoediting; elimination; escape;

D O I：

10.1189/jlb.1107774

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This brief review discusses the role of the immune system in tumor development, covering a history of cancer immunity and a summary of the concept of cancer immunoediting, including its three phases: elimination, equilibrium, and escape. The latter half of this review then focuses specifically on the equilibrium phase, making note of previous work, suggesting that immunity might maintain cancer in a dormant state, and concluding with a description of a tractable mouse model unequivocally demonstrating that immunity can indeed hold preformed cancer in check. These findings form a framework for future studies aimed at validating immune-mediated cancer dormancy in humans with the hopes of devising new, immunotherapeutic strategies to treat established cancer.

引用

页码：988 / 993

页数：6

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