The prognosis of idiopathic generalized epilepsy

被引:69
作者
Seneviratne, Udaya [1 ,2 ]
Cook, Mark [1 ]
D'Souza, Wendyl [1 ,3 ]
机构
[1] Univ Melbourne, St Vincents Hosp, Dept Med, Fitzroy, Vic 3065, Australia
[2] Monash Med Ctr, Dept Neurosci, Melbourne, Vic, Australia
[3] Univ Melbourne, Melbourne Sch Populat Hlth, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
Epilepsy; Electroencephalography; Long-term outcome; Remission; Predictors; JUVENILE MYOCLONIC EPILEPSY; LONG-TERM PROGNOSIS; CHILDHOOD ABSENCE EPILEPSY; NEWLY-DIAGNOSED EPILEPSY; SPIKE-WAVE DISCHARGES; NEW-ONSET EPILEPSY; FOLLOW-UP; NEUROPSYCHOLOGICAL STATUS; NATURAL-HISTORY; CHILDREN;
D O I
10.1111/j.1528-1167.2012.03723.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Prognosis describes the trajectory and long-term outcome of a condition. Most studies indicate a better prognosis in idiopathic generalized epilepsy (IGE) in comparison with other epilepsy syndromes. Studies looking at the long-term outcome of different IGE syndromes are relatively scant. Childhood absence epilepsy appears to have a higher rate of remission compared to juvenile absence epilepsy. In absence epilepsies, development of myoclonus and generalized tonicclonic seizures predicts lower likelihood of remission. Although most patients with juvenile myoclonic epilepsy (JME) achieve remission on antiepileptic drug therapy, <20% appear to remain in remission without treatment. Data on the prognosis of other IGE syndromes are scarce. There are contradictory findings reported on the value of electroencephalography as a predictor of prognosis. Comparisons are made difficult by study heterogeneity, particularly in methodology and diagnostic criteria.
引用
收藏
页码:2079 / 2090
页数:12
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