Furan oligomers and β-carbolines from terrestrial streptomycetes

被引：37

作者：

Fotso, Serge ^{[1
]}

Maskey, Rajendra P. ^{[1
]}

Schroeder, Dirk ^{[1
]}

Ferrer, Anna S. ^{[1
]}

Gruen-Wollny, Iris ^{[2
]}

Laatsch, Hartmut ^{[1
]}

机构：

[1] Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Lab Grun Wollny, D-35394 Giessen, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 09期

关键词：

D O I：

10.1021/np800248s

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

2,5-Bis(hydroxymethyl)furan monoacetate (3) and 2,5 -bis(hydroxymethyl)furan diacetate (4) were obtained as new natural products from an ethyl acetate extract of the terrestrial Streptomyces sp. isolate GW11/1695. Another Streptomyces isolate. GW21/1313, delivered a dimer (6) and a trimer (7) of (hydroxymethyl)furfural. The latter strain also produced 4-hydroxy-2-(5 -(hydroxymethyl)furan-2-ylmethylene)-5-methylfuran-3-one (5), perlolyrin (8), and two new beta-carboline derivatives, 9 and 10. 2,5-Bis(hydroxymethyl)furan diacetate (4) exhibited weak cytotoxic activity against brine shrimp larvae.

引用

页码：1630 / 1633

页数：4

共 24 条

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