Synthesis and Antimicrobial Activity of Carboxylate Phosphabetaines Derivatives with Alkyl Chains of Various Lengths

被引：19
|
作者：
Galkina, Irina V. [1 ]
Bakhtiyarova, Yuliya V. [1 ]
Shulaeva, Marina P. [2 ]
Pozdeev, Oskar K. [2 ]
Egorova, Svetlana N. [3 ]
Cherkasov, Rafael A. [1 ]
Galkin, Vladimir I. [1 ]
机构：
[1] Kazan Fed Univ, AM Butlerov Chem Inst, Dept High Mol & Organoelement Cpds, Kazan 420008, Russia
[2] Kazan State Med Acad, Dept Microbiol, Kazan 420012, Russia
[3] Kazan State Med Univ, Dept Pharmacol, Kazan 420012, Russia
来源：
JOURNAL OF CHEMISTRY | 2013年 / 2013卷
关键词：
SUSCEPTIBILITY; TRIPHENYLPHOSPHINE; ACIDS;
D O I：
10.1155/2013/302937
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The purpose of the present study was to investigate the antibacterial activity of fifteen novel nanosized alkyl esters of carboxylate phosphabetaine: beta-(carboxyalkyl)ethyltriphenylphosphonium bromides 4-8, beta-(carboxyalkyl)-beta-methylethyltriphenylphosphonium bromides 9-13, and beta-(carboxyalkyl)-alpha-methylethyltriphenylphosphonium bromides 14-18. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive and gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate that the synthesized phosphonium salts 4-18 possess a broad spectrum of activity against the tested microorganisms. Every newly synthesized compound was characterized by elemental analyses, IR H-1 NMR, and P-31 NMR spectral studies.
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页数：6
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