Synthesis and Antimicrobial Activity of Carboxylate Phosphabetaines Derivatives with Alkyl Chains of Various Lengths

被引：22

作者：

Galkina, Irina V. ^{[1
]}

Bakhtiyarova, Yuliya V. ^{[1
]}

Shulaeva, Marina P. ^{[2
]}

Pozdeev, Oskar K. ^{[2
]}

Egorova, Svetlana N. ^{[3
]}

Cherkasov, Rafael A. ^{[1
]}

Galkin, Vladimir I. ^{[1
]}

机构：

[1] Kazan Fed Univ, AM Butlerov Chem Inst, Dept High Mol & Organoelement Cpds, Kazan 420008, Russia

[2] Kazan State Med Acad, Dept Microbiol, Kazan 420012, Russia

[3] Kazan State Med Univ, Dept Pharmacol, Kazan 420012, Russia

来源：

JOURNAL OF CHEMISTRY | 2013年 / 2013卷

关键词：

SUSCEPTIBILITY; TRIPHENYLPHOSPHINE; ACIDS;

D O I：

10.1155/2013/302937

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The purpose of the present study was to investigate the antibacterial activity of fifteen novel nanosized alkyl esters of carboxylate phosphabetaine: beta-(carboxyalkyl)ethyltriphenylphosphonium bromides 4-8, beta-(carboxyalkyl)-beta-methylethyltriphenylphosphonium bromides 9-13, and beta-(carboxyalkyl)-alpha-methylethyltriphenylphosphonium bromides 14-18. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive and gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate that the synthesized phosphonium salts 4-18 possess a broad spectrum of activity against the tested microorganisms. Every newly synthesized compound was characterized by elemental analyses, IR H-1 NMR, and P-31 NMR spectral studies.

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