Synthesis and Antimicrobial Activity of Carboxylate Phosphabetaines Derivatives with Alkyl Chains of Various Lengths

被引：19
|
作者：
Galkina, Irina V. [1 ]
Bakhtiyarova, Yuliya V. [1 ]
Shulaeva, Marina P. [2 ]
Pozdeev, Oskar K. [2 ]
Egorova, Svetlana N. [3 ]
Cherkasov, Rafael A. [1 ]
Galkin, Vladimir I. [1 ]
机构：
[1] Kazan Fed Univ, AM Butlerov Chem Inst, Dept High Mol & Organoelement Cpds, Kazan 420008, Russia
[2] Kazan State Med Acad, Dept Microbiol, Kazan 420012, Russia
[3] Kazan State Med Univ, Dept Pharmacol, Kazan 420012, Russia
来源：
JOURNAL OF CHEMISTRY | 2013年 / 2013卷
关键词：
SUSCEPTIBILITY; TRIPHENYLPHOSPHINE; ACIDS;
D O I：
10.1155/2013/302937
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The purpose of the present study was to investigate the antibacterial activity of fifteen novel nanosized alkyl esters of carboxylate phosphabetaine: beta-(carboxyalkyl)ethyltriphenylphosphonium bromides 4-8, beta-(carboxyalkyl)-beta-methylethyltriphenylphosphonium bromides 9-13, and beta-(carboxyalkyl)-alpha-methylethyltriphenylphosphonium bromides 14-18. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive and gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate that the synthesized phosphonium salts 4-18 possess a broad spectrum of activity against the tested microorganisms. Every newly synthesized compound was characterized by elemental analyses, IR H-1 NMR, and P-31 NMR spectral studies.
引用
收藏
页数：6
相关论文
共 50 条
  • [1] Synthesis and biological evaluation of novel carboxylate phosphabetaines derivatives with long alkyl chains
    Galkina, Irina V.
    Aksunova, Alfiya F.
    Bakhtiyarov, Dmitriy I.
    Shulaeva, Marina P.
    Pozdeev, Oskar K.
    Egorova, Svetlana N.
    Bakhtiyarova, Yuliya V.
    Galkin, Vladimir I.
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2016, 191 (11-12) : 1676 - 1678
  • [2] Synthesis and Antimicrobial Activity of Some Cross-linked Copolymers with Alkyl Chains of Various Lengths
    Zhang, Yuhong
    Li, Xiaohong
    Dong, Qinzheng
    He, Peixin
    JOURNAL OF APPLIED POLYMER SCIENCE, 2011, 120 (03) : 1767 - 1773
  • [3] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF DIMETHYL-SUBSTITUTED AND TRIMETHYL-SUBSTITUTED PHOSPHONIUM SALTS WITH ALKYL CHAINS OF VARIOUS LENGTHS
    KANAZAWA, A
    IKEDA, T
    ENDO, T
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (05) : 945 - 952
  • [4] Synthesis, structure and bioactivity of novel carboxylate phosphabetaine derivatives with long alkyl chains
    Minnullin, Rail R.
    Bakhtiyarova, Yulia V.
    Morozov, Maxim V.
    Bakhtiyarov, Dmitry I.
    Shulaeva, Marina P.
    Oskar, K. Pozdeev
    Gerasimov, Aleksandr V.
    Galkina, Irina V.
    Galkin, Vladimir I.
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2019, 194 (4-6) : 476 - 479
  • [5] Synthesis and Antimicrobial Activity of 8-Alkyl Coptisine Derivatives
    Jiang, Xiao-Fei
    Ye, Xiao-Li
    Zhang, Baoshun
    Li, Xue-Gang
    Liu, Xingyan
    ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (09) : 3849 - 3852
  • [6] Novel approaches to the chemical synthesis and characterization of alkyl phenols derivatives with various side chains
    Lo, Yu-Chen
    Hsiao, Meen-Woon
    Honda, Hiroshi
    Wei, Tsao-Yi
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [7] Novel approaches to the chemical synthesis and characterization of alkyl phenols derivatives with various side chains
    Ren, Gui
    Parish, Edward
    Honda, Hiroshi
    Hsiao, Meen-Woon
    Wei, Tsao-Yi
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
  • [8] Synthesis, Characterization, and Antimicrobial Activity of Methyl-2-aminopyridine-4-carboxylate Derivatives
    Nagashree, S.
    Mallu, P.
    Mallesha, L.
    Bindya, S.
    JOURNAL OF CHEMISTRY, 2013, 2013
  • [9] Synthesis and antimicrobial activity of new S-alkyl isothiosemicarbazone derivatives of pyrimidine
    Raundal, Hemant N.
    Jadhav, Rahul P.
    Patil, Amar A.
    Mhaske, Pravin C.
    Bobade, Vivek D.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2015, 54 (04): : 565 - 569
  • [10] Synthesis and antimicrobial activity of β-carboline derivatives with N2-alkyl modifications
    Suzuki, Kenji
    Nomura, Itsuki
    Ninomiya, Masayuki
    Tanaka, Kaori
    Koketsu, Mamoru
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (17) : 2976 - 2978
12345