Aggregation-induced folding of a de novo designed polypeptide immobilized on gold nanoparticles

被引：70

作者：

Aili, D

Enander, K

Rydberg, J

Lundström, I

Baltzer, L

Liedberg, B ^{[1
]}

机构：

[1] Linkoping Univ, Dept Phys Chem & Biol, IFM, SE-58183 Linkoping, Sweden

[2] Univ Uppsala, BMC, Dept Chem, SE-75124 Uppsala, Sweden

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 07期

关键词：

D O I：

10.1021/ja057056j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This communication reports the first steps in the construction of a novel, nanoparticle-based hybrid material for biomimetic and biosensor applications. Gold nanoparticles were modified with synthetic polypeptides to enable control of the particle aggregation state in a switchable manner, and particle aggregation was, in turn, found to induce folding of the immobilized peptides. Copyright © 2006 American Chemical Society.

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页码：2194 / 2195

页数：2

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