Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon

被引：96

作者：

Chiu, Yvonne E. ^{[1
]}

Drolet, Beth A. ^{[1
]}

Blei, Francine ^{[2
]}

Carcao, Manuel ^{[3
]}

Fangusaro, Jason ^{[4
]}

Kelly, Michael E. ^{[5
]}

Krol, Alfons ^{[6
]}

Lofgren, Sabra ^{[6
]}

Mancini, Anthony J. ^{[7
]}

Metry, Denise W. ^{[8
]}

Recht, Michael ^{[9
]}

Silverman, Robert A. ^{[10
]}

Tom, Wynnis L. ^{[11
]}

Pope, Elena ^{[12
]}

机构：

[1] Med Coll Wisconsin, Dept Dermatol, Div Pediat Dermatol, Milwaukee, WI 53226 USA

[2] Vasc Birthmark Inst New York, New York, NY USA

[3] Univ Toronto, Dept Paediat, Div Haematol Oncol, Toronto, ON M5S 1A1, Canada

[4] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Div Hematol Oncol Stem Cell Transplantat, Chicago, IL 60611 USA

[5] Med Coll Wisconsin, Dept Pediat, Div Hematol Oncol Blood & Marrow Transplant, Milwaukee, WI 53226 USA

[6] Oregon Hlth & Sci Univ, Dept Dermatol, Div Pediat Dermatol, Portland, OR 97201 USA

[7] Northwestern Univ, Dept Dermatol, Feinberg Sch Med, Div Pediat Dermatol, Chicago, IL 60611 USA

[8] Baylor Coll Med, Dept Dermatol, Div Pediat Dermatol, Houston, TX 77030 USA

[9] Oregon Hlth & Sci Univ, Dept Pediat, Div Hematol Oncol, Portland, OR 97201 USA

[10] Georgetown Univ, Dept Pediat, Div Pediat Dermatol, Washington, DC 20057 USA

[11] Univ Calif San Diego, Dept Med, Div Dermatol, San Diego, CA 92103 USA

[12] Univ Toronto, Dept Paediat, Div Paediat Med, Dermatol Sect, Toronto, ON M5S 1A1, Canada

来源：

PEDIATRIC BLOOD & CANCER | 2012年 / 59卷 / 05期

关键词：

Kasabach-Merritt; kaposiform hemangioendothlioma; propranolol; treatment; tufted angioma; vascular tumor; VINCRISTINE; HEMANGIOMAS; CHILDHOOD; INFANCY;

D O I：

10.1002/pbc.24103

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Propranolol is a non-selective beta-adrenergic antagonist successfully used in a case of kaposiform hemangioendothelioma (KHE) associated with KasabachMerritt phenomenon (KMP). We report 11 patients treated with propranolol for KHE and the related variant tufted angioma (TA), six of whom also had KMP. The varied responses to treatment, with only 36% responding in our series, demonstrate the need for further study of this medication before routine use for these indications. Pediatr Blood Cancer 2012; 59: 934938. (C) 2012 Wiley Periodicals, Inc.

引用

页码：934 / 938

页数：5

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