Advances in Sepsis Research

被引：19
作者：
Bentzer, Peter [1 ,2 ,3 ]
Russell, James A. [1 ,2 ]
Walley, Keith R. [1 ,2 ]
机构：
[1] Univ British Columbia, Ctr Heart Lung Innovat, Vancouver, BC V6Z 1Y6, Canada
[2] Univ British Columbia, St Pauls Hosp, Div Crit Care Med, Vancouver, BC V6Z 1Y6, Canada
[3] Lund Univ, Dept Anesthesiol & Intens Care, SE-22185 Lund, Sweden
来源：
CLINICS IN CHEST MEDICINE | 2015年 / 36卷 / 03期
关键词：
Sepsis; Innate immune receptors; Pathogen; Clearance; Edema; Vascular leak; ACTIVATED PROTEIN-C; CANDIDA-ALBICANS PHOSPHOLIPOMANNAN; LEFT-VENTRICULAR CONTRACTILITY; SPHINGOSINE; 1-PHOSPHATE; PLASMA-VOLUME; CARDIOMYOCYTE CONTRACTILITY; NOREPINEPHRINE INFUSION; INFLAMMATORY RESPONSE; PATHOGEN RECOGNITION; BARRIER PROTECTION;
D O I：
10.1016/j.ccm.2015.05.009
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Recent research has identified promising targets for therapeutic interventions aimed at modulating the inflammatory response in sepsis. Herein, the authors describe mechanisms involved in the clearance of pathogen toxin from the circulation and potential interventions aimed at enhancing clearance mechanisms. The authors also describe advances in the understanding of the innate immune response as potential therapeutic targets. Finally, novel potential treatment strategies aimed at decreasing vascular leak are discussed.
引用
收藏
页码：521 / +
页数：11
相关论文
共 75 条
[21]   ACTIVATED PROTEIN C IMPROVES MACROVASCULAR AND MICROVASCULAR REACTIVITY IN HUMAN SEVERE SEPSIS AND SEPTIC SHOCK [J].
Favory, Raphael ;
Poissy, Julien ;
Alves, Isabelle ;
Guerry, Mary-Jane ;
Lemyze, Malcolm ;
Parmentier-Decrucq, Erika ;
Duburcq, Thibault ;
Mathieu, Daniel .
SHOCK, 2013, 40 (06) :512-518
[22]   Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation [J].
Feistritzer, C ;
Riewald, M .
BLOOD, 2005, 105 (08) :3178-3184
[23]   NEGATIVE INOTROPIC EFFECTS OF CYTOKINES ON THE HEART MEDIATED BY NITRIC-OXIDE [J].
FINKEL, MS ;
ODDIS, CV ;
JACOB, TD ;
WATKINS, SC ;
HATTLER, BG ;
SIMMONS, RL .
SCIENCE, 1992, 257 (5068) :387-389
[24]   Deactivation of the lipopolysaccharide antagonist eritoran (E5564) by high-density lipoprotein-associated apolipoproteins [J].
Fleischer, Jacklyn G. ;
Rossignol, Dan ;
Francis, Gordon A. ;
Chan, Teddy ;
Lynn, Melvyn ;
Wasan, Kishor M. .
INNATE IMMUNITY, 2012, 18 (01) :171-178
[25]   MODE OF ACTION OF ANTI-LIPOPOLYSACCHARIDE-BINDING PROTEIN ANTIBODIES FOR PREVENTION OF ENDOTOXEMIC SHOCK IN MICE [J].
GALLAY, P ;
HEUMANN, D ;
LEROY, D ;
BARRAS, C ;
GLAUSER, MP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (17) :7922-7926
[26]   Effect of plasma phospholipid transfer protein deficiency on lethal endotoxemia in mice [J].
Gautier, Thomas ;
Klein, Alexis ;
Deckert, Valerie ;
Desrumaux, Catherine ;
Ogier, Nicolas ;
Sberna, Anne-Laure ;
Paul, Catherine ;
Le Guern, Naig ;
Athias, Anne ;
Montange, Thomas ;
Monier, Serge ;
Piard, Francoise ;
Jiang, Xian-Cheng ;
Masson, David ;
Lagrost, Laurent .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (27) :18702-18710
[27]   Leukocyte activation does not mediate myocardial leukocyte retention during endotoxemia in rabbits [J].
Goddard, CM ;
Poon, BY ;
Klut, ME ;
Wiggs, BR ;
vanEeden, SF ;
Hogg, JC ;
Walley, ER .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1998, 275 (05) :H1548-H1557
[28]   Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein [J].
Hailman, E ;
Albers, JJ ;
Wolfbauer, G ;
Tu, AY ;
Wright, SD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (21) :12172-12178
[29]   CHYLOMICRONS ALTER THE FATE OF ENDOTOXIN, DECREASING TUMOR-NECROSIS-FACTOR RELEASE AND PREVENTING DEATH [J].
HARRIS, HW ;
GRUNFELD, C ;
FEINGOLD, KR ;
READ, TE ;
KANE, JP ;
JONES, AL ;
EICHBAUM, EB ;
BLAND, GF ;
RAPP, JH .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (03) :1028-1034
[30]  
Hattori Y, 1997, BIOCHEM MOL BIOL INT, V41, P979
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