Advances in Sepsis Research

被引：19
作者：
Bentzer, Peter [1 ,2 ,3 ]
Russell, James A. [1 ,2 ]
Walley, Keith R. [1 ,2 ]
机构：
[1] Univ British Columbia, Ctr Heart Lung Innovat, Vancouver, BC V6Z 1Y6, Canada
[2] Univ British Columbia, St Pauls Hosp, Div Crit Care Med, Vancouver, BC V6Z 1Y6, Canada
[3] Lund Univ, Dept Anesthesiol & Intens Care, SE-22185 Lund, Sweden
来源：
CLINICS IN CHEST MEDICINE | 2015年 / 36卷 / 03期
关键词：
Sepsis; Innate immune receptors; Pathogen; Clearance; Edema; Vascular leak; ACTIVATED PROTEIN-C; CANDIDA-ALBICANS PHOSPHOLIPOMANNAN; LEFT-VENTRICULAR CONTRACTILITY; SPHINGOSINE; 1-PHOSPHATE; PLASMA-VOLUME; CARDIOMYOCYTE CONTRACTILITY; NOREPINEPHRINE INFUSION; INFLAMMATORY RESPONSE; PATHOGEN RECOGNITION; BARRIER PROTECTION;
D O I：
10.1016/j.ccm.2015.05.009
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Recent research has identified promising targets for therapeutic interventions aimed at modulating the inflammatory response in sepsis. Herein, the authors describe mechanisms involved in the clearance of pathogen toxin from the circulation and potential interventions aimed at enhancing clearance mechanisms. The authors also describe advances in the understanding of the innate immune response as potential therapeutic targets. Finally, novel potential treatment strategies aimed at decreasing vascular leak are discussed.
引用
收藏
页码：521 / +
页数：11
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