Potential anti-cancer activity of a novel Bi(III) containing thiosemicarbazone derivative

被引：11

作者：

Ouyang, Ruizhuo ^{[1
]}

Yang, Yang ^{[1
]}

Tong, Xiao ^{[2
]}

Yang, Yaoqin ^{[2
]}

Tao, Huihong ^{[2
]}

Zong, Tianyu ^{[1
]}

Feng, Kai ^{[1
]}

Jia, Pengpeng ^{[1
]}

Cao, Penghui ^{[1
]}

Guo, Ning ^{[1
]}

Chang, Haizhou ^{[1
]}

Zhou, Shuang ^{[2
]}

Miao, Yuqing ^{[1
]}

机构：

[1] Univ Shanghai Sci & Technol, Shanghai 200093, Peoples R China

[2] Tongji Univ, Inst Canc, Sch Med, Shanghai 200092, Peoples R China

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2016年 / 73卷

基金：

中国国家自然科学基金;

关键词：

Bi(III) complex; Thiosemicarbazone derivative; Anti-cancer ability; Lung cancer; A549 and H460; BIOLOGICAL EVALUATION; CRYSTAL-STRUCTURE; IN-VITRO; BISMUTH COMPOUNDS; COMPLEXES; CYTOTOXICITY; TOXICITY; CELLS;

D O I：

10.1016/j.inoche.2016.10.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

By mixing 5-bromo-2-furaldehyde, phenylthiosemicarbazide and Bi(CH3COO)(3), a new amorphous bismuth-containing complex, BiL2Cl3, was synthesized under aqueous conditions via a one-pot method and characterized with some analytical techniques, where L was produced by dehydration between 5-bromo-2-furaldehyde, phenylthiosemicarbazide. The obtained complex effectively inhibited the proliferation and migration of A549 and H460 lung cancer cells, induced cell apoptosis and displayed fairly low cytotoxicity to normal human lung fibroblast (HLF). Compared with cisplatin, BiL2Cl3 displayed better anti-cancer activity against tumor cells and lower toxicity to normal cell. Therefore, BiL2Cl3 with potent anti-cancer activity may be a viable drug candidate in anti-cancer therapies. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：138 / 141

页数：4

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