Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachloride-induced Hepatotoxicity in Rats

被引：27

作者：

Ullah, Riaz ^{[1
,2
,3
]}

Alsaid, Mansour S. ^{[1
,2
]}

Shahat, Abdelaaty A. ^{[1
,2
,4
]}

Naser, Almoqbil Abdulaziz ^{[1
,2
]}

Al-Mishari, Abdullah A. ^{[1
,2
]}

Adnan, Muhammad ^{[5
]}

Tariq, Akash ^{[6
,7
,8
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmacognosy, POB 2457, Riyadh 11451, Saudi Arabia

[2] King Saud Univ, Coll Pharm, MAPPRC, POB 2457, Riyadh 11451, Saudi Arabia

[3] Govt Coll Ara Khel FR Kohat KPK Pakistan, Dept Chem, Kohat, Pakistan

[4] Natl Res Ctr, Phytochem Dept, 33 El Bohouth St,POB12622, Giza, Egypt

[5] Kohat Univ Sci & Technol KUST KPK Pakistan, Dept Bot, Kohat, Pakistan

[6] Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat f, Chengdu 610041, Sichuan, Peoples R China

[7] Chinese Acad Sci, Chengdu Inst Biol, Ecol Restorat Biodivers Conservat Key Lab Sichuan, Chengdu 610041, Sichuan, Peoples R China

[8] 6Univ Chinese Acad Sci, Beijing, Peoples R China

来源：

OPEN CHEMISTRY | 2018年 / 16卷 / 01期

关键词：

Z; spinosa; H; elegans; hepatoprotective; LIVER;

D O I：

10.1515/chem-2018-0021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The detoxification, metabolism, and excretion of various endogenous and exogenous materials occur mainly in the liver. Liver diseases are a global concern, and classified as chronic hepatitis, cirrhosis, and hepatosis. The development of safe hepatoprotective agents remains an unmet need. Therefore, we investigated the antioxidant effects of methanolic and n-hexane fractions of Zilla spinosa (ZSM and ZSH, respectively) and Hammada elegans (HEM and HEH, respectively) against carbon tetrachloride (CCl4)-induced liver toxicity in rats. Antioxidant activity was studied by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The rats were divided into 11 groups (n=6)-group 1 (control), group 2 (CCl4 only), group 3 (CCl4 + silymarin 10 mg/kg), group 4 (CCl4 + HEM 250 mg/kg), group 5 (CCl4 + HEM 500 mg/kg), group 6 (CCl4 + HEH 250 mg/kg), group 7 (CCl4 + HEH 500 mg/kg), group 8 (CCl4 + ZSM 250 mg/kg),

引用

页码：133 / 140

页数：8

共 33 条

[1]

Adewusi EA, 2010, J MED PLANTS RES, V4, P1318

[2]

AJABNOOR M A, 1984, Fitoterapia, V55, P107

[3] Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status [J].