What Is the Brain-Cancer Connection?

被引:49
作者
Cao, Lei [1 ]
During, Matthew J. [1 ]
机构
[1] Ohio State Univ, Coll Med, Columbus, OH 43210 USA
来源
ANNUAL REVIEW OF NEUROSCIENCE, VOL 35 | 2012年 / 35卷
关键词
environmental enrichment; hypothalamic-sympathoneural-adipocyte (HSA) axis; BDNF; adipocyte; leptin; BODY-MASS INDEX; ENDOTHELIAL GROWTH-FACTOR; STRESSFUL LIFE EVENTS; BREAST-CANCER; TUMOR-GROWTH; PSYCHOSOCIAL FACTORS; SOCIAL-ISOLATION; GENE-EXPRESSION; BETA-BLOCKERS; CELL-LINES;
D O I
10.1146/annurev-neuro-062111-150546
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A focus of much cancer research is at the molecular and cellular levels. In contrast, the effects of social interactions and psychological state are less investigated, and considered by many a "soft" science. Yet several highly rigorous studies have begun to tease out biochemical pathways by which the brain can influence the development and growth of cancer. Previous reviews have discussed the concept of stress and cancer. Here, we discuss recent work showing environments that are more complex and challenging, but not stressful per se, and that have robust effects on peripheral cancer by activating a specific neuroendocrine brain-adipocyte axis. These enriched environments lead to activation of the sympathetic innervation of fat tissue, suppression of leptin, and a reduction in cancer proliferation by inducing hypothalamic BDNF expression. We summarize this work and discuss how these data integrate into the body of literature regarding stress, the environment, and cancer.
引用
收藏
页码:331 / 345
页数:15
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