Protection of Mice against X-ray Injuries by the Post-irradiation Administration of Inosine-5′-monophosphate

被引：8

作者：

Asadullina, Nelli R. ^{[1
]}

Usacheva, Anna M. ^{[1
]}

Gudkov, Sergey V. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia

[2] Pushchino State Univ, Pushchino 142290, Moscow Region, Russia

来源：

JOURNAL OF RADIATION RESEARCH | 2012年 / 53卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

Inosine-5 '-monophosphate; Ionizing radiation; Mitigator; Radioprotector; RADIATION; RADIOPROTECTORS; NUCLEOTIDES; NUCLEOSIDES; GUANOSINE;

D O I：

10.1269/jrr.11050

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of the present study was to investigate the radiation modulating properties of inosine-5'-monophosphate (IMP). Mice injected introperitoneally (i.p.) with IMP 15 minutes after irradiation with a lethal irradiation dose of 7 Gy have better survival rates comparative to irradiated mice non treated with IMP. The dose reduction factor of the IMP is 1.22. Using a hematologdical test we demonstrated that administration of IMP alleviates the symptoms of radiation-induced leukopenia and thrombocytopenia. The DNA damage in bone marrow and thymus cells of irradiated mice was measured by flow cytofluorometry and micronucleus test (MN-test). The tests show that i.p. administration of IMP to irradiated animals leads to a significant reduction of the DNA damage level. In this paper we show that IMP substantially modulates the damaging effects of ionizing radiation protecting irradiated mice and it is a promising agent for a treatment of leukopenia.

引用

页码：211 / 216

页数：6

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