Non-lithographic wrinkle nanochannels for protein preconcentration

被引：116

作者：

Chung, Seok ^{[1
]}

Lee, Jeong Hoon ^{[2
]}

Moon, Myoung-Woon ^{[3
,4
]}

Han, Jongyoon ^{[2
]}

Kamm, Roger D. ^{[1
]}

机构：

[1] MIT, Dept Mech Engn & Biol Engn, Cambridge, MA 02139 USA

[2] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[3] Harvard Univ, Div Engn & Appl Sci, Cambridge, MA 02138 USA

[4] Korea Inst Sci & Technol, Future Fus Technol Lab, Seoul 136791, South Korea

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 16期

关键词：

D O I：

10.1002/adma.200701715

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, non-lithographic method to create a nanofluidic channel array that exploits wrinkles is demonstrated. The dimension and position of the wrinkles can be precisely controlled, producing wrinkle nanochannels (WNCs) that range in size from several tens of nanometers to micrometers. The usefulness of the WNCs is demonstrated by preconcentration of a protein, which is shown to vary linearly. Preconcentration levels of more than 100 can be achieved within 10 minutes.

引用

页码：3011 / 3016

页数：6

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