Magneto-Electric Nano-Particles for Non-Invasive Brain Stimulation

被引：105

作者：

Yue, Kun ^{[1
]}

Guduru, Rakesh ^{[1
]}

Hong, Jeongmin ^{[1
]}

Liang, Ping ^{[3
]}

Nair, Madhavan ^{[1
,2
]}

Khizroev, Sakhrat ^{[1
,2
]}

机构：

[1] Florida Int Univ, Coll Engn & Comp, Ctr Nanomed, Miami, FL 33199 USA

[2] Florida Int Univ, Herbert Wertheim Coll Med, Inst NeuroImmune Pharmacol, Dept Immunol, Miami, FL 33199 USA

[3] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA

来源：

PLOS ONE | 2012年 / 7卷 / 09期

基金：

美国国家科学基金会;

关键词：

TRANSCRANIAL MAGNETIC STIMULATION; EXCITABILITY;

D O I：

10.1371/journal.pone.0044040

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This paper for the first time discusses a computational study of using magneto-electric (ME) nanoparticles to artificially stimulate the neural activity deep in the brain. The new technology provides a unique way to couple electric signals in the neural network to the magnetic dipoles in the nanoparticles with the purpose to enable a non-invasive approach. Simulations of the effect of ME nanoparticles for non-invasively stimulating the brain of a patient with Parkinson's Disease to bring the pulsed sequences of the electric field to the levels comparable to those of healthy people show that the optimized values for the concentration of the 20-nm nanoparticles (with the magneto-electric (ME) coefficient of 100 V cm(-1) Oe(-1) in the aqueous solution) is 3 x 10(6) particles/cc, and the frequency of the externally applied 300-Oe magnetic field is 80 Hz.

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