Synthesis and antibacterial evaluation of Cu(II) and Zn(II) complexes of the β-lactum antibiotic, cefdinir

被引：9
|
作者：
Sharma, Deepika [1 ]
Kumar, Pradeep [2 ]
Narasimhan, Balasubramanian [2 ]
机构：
[1] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India
[2] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 06期
关键词：
Cefdinir; Copper complex; Zinc complex; Antibacterial activity; ANTIMICROBIAL ACTIVITY; COPPER(II) COMPLEXES; DERIVATIVES; ACID; QSAR; INHIBITION;
D O I：
10.1007/s00044-011-9588-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study, the coordination chemistry of the antibiotic, cefdinir, and its metal complexes with Cu (II) and Zn (II) was described and characterized on the basis of analytical and spectral studies. The synthesized complexes were evaluated in vitro for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli. The metal complexes possessed the better antibacterial activity against the selected species of bacteria than the free antibiotic (cefdinir). The results were supported by the increase in log P values of metal complexes in comparison to the free ligand cefdinir. The importance of these findings lies in the fact that these complexes could be applied in the treatment of common bacterial infections.
引用
收藏
页码：796 / 803
页数：8
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