Mechanism of Cellular Uptake of Graphene Oxide Studied by Surface-Enhanced Raman Spectroscopy

被引：208

作者：

Huang, Jie ^{[3
]}

Zong, Cheng ^{[1
,2
]}

Shen, He ^{[3
]}

Liu, Min ^{[3
]}

Chen, Biao ^{[3
]}

Ren, Bin ^{[1
,2
]}

Zhang, Zhijun ^{[3
]}

机构：

[1] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Dept Chem, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Peoples R China

[3] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Suzhou 215125, Peoples R China

来源：

SMALL | 2012年 / 8卷 / 16期

关键词：

GOLD NANOPARTICLES; DELIVERY; SCATTERING;

D O I：

10.1002/smll.201102743

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The last few years have witnessed rapid development of biological and medical applications of graphene oxide (GO), such as drug/gene delivery, biosensing, and bioimaging. However, little is known about the cellular uptake mechanism and pathway of GO. In this work, surface-enhanced Raman scattering (SERS) spectroscopy is employed to investigate the cellular internalization of GO loaded with Au nanoparticles (NPs) by Ca Ski cells. The presence of Au NPs on the surface of GO enables detection of enhanced intrinsic Raman signals of GO inside the cell. The SERS results reveal that GO is distributed inhomogeneously inside the cell. Furthermore, internalization of Au-GO into Ca Ski cells is mainly via clathrin-mediated endocytosis, and is an energy-dependent process.

引用

页码：2577 / 2584

页数：8

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