Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?

被引：35
作者：
Di Virgilio, Francesco [1 ]
Giuliani, Anna Lisa [1 ]
机构：
[1] Univ Ferrara, Dept Morphol Surg & Expt Med, Via Savonarola 9, I-44121 Ferrara, FE, Italy
来源：
BIOMEDICAL JOURNAL | 2016年 / 39卷 / 05期
关键词：
Extracellular ATP; P2X7R; Systemic lupus erythematosus; NLRP3; inflammasome; Interleukin-1; beta; NF-KAPPA-B; P2X(7) RECEPTOR ACTIVATION; EXTRACELLULAR ATP; NLRP3; INFLAMMASOME; ION-CHANNEL; GENE POLYMORPHISMS; ADENOSINE 5'-TRIPHOSPHATE; IL-1-BETA RELEASE; HISTAMINE-RELEASE; MOUSE LYMPHOCYTES;
D O I：
10.1016/j.bj.2016.08.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Purinergic signalling plays a crucial role in immunity and autoimmunity. Among purinergic receptors, the P2X7 receptor (P2X7R) has an undisputed role as it is expressed to high level by immune cells, triggers cytokine release and modulates immune cell differentiation. In this review, we focus on evidence supporting a possible role of the P2X7R in the pathogenesis of systemic lupus erythematosus (SLE).
引用
收藏
页码：326 / 338
页数：13
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