Is there a local renin-angiotensin system in the heart?

被引：69
作者：
Danser, AHJ [1 ]
Saris, JJ
Schuijt, MP
van Kats, JP
机构：
[1] Erasmus Univ, Dept Pharmacol, COEUR, Cardiovasc Res Inst, NL-3015 GE Rotterdam, Netherlands
[2] Erasmus Univ, Dept Internal Med 1, COEUR, Cardiovasc Res Inst, NL-3015 GE Rotterdam, Netherlands
来源：
CARDIOVASCULAR RESEARCH | 1999年 / 44卷 / 02期
关键词：
angiotensin; ACE inhibitors; interstitial space; myocytes; renin angiotensin system;
D O I：
10.1016/S0008-6363(99)00202-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The existence of a local renin-angiotensin system in the heart is still a controversial issue. This review discusses the evidence, obtained from studies in cardiac cells, in isolated perfused hearts and in intact animals and humans, both under normal and pathological conditions, for local production of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, angiotensin I and angiotensin II at cardiac tissue sites. In addition, the role of alternative angiotensin-generating enzymes (cathepsin, chymase) and the possibility of (pro)renin uptake from the circulation is evaluated. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：252 / 265
页数：14
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