Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo via downregulating the ERK-MAPK pathway

被引：73
作者：
Wu, Shuai [1 ,2 ,3 ]
Lao, Xin-Yuan [4 ]
Sun, Tian-Tian [1 ,2 ,3 ]
Ren, Lin-Lin [1 ,2 ,3 ]
Kong, Xuan [1 ,2 ,3 ]
Wang, Ji-Lin [1 ,2 ,3 ]
Wang, Ying-Chao [1 ,2 ,3 ]
Du, Wan [1 ,2 ,3 ]
Yu, Ya-Nan [1 ,2 ,3 ]
Weng, Yu-Rong [1 ,2 ,3 ]
Hong, Jie [1 ,2 ,3 ]
Fang, Jing-Yuan [1 ,2 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, GI Div, Sch Med, Renji Hosp,Shanghai Inst Digest Dis, Shanghai 200001, Peoples R China
[2] Shanghai Jiao Tong Univ, Key Lab Gastroenterol & Hepatol, Minist Hlth, Shanghai 200001, Peoples R China
[3] State Key Lab Oncogene & Related Genes, Shanghai 200001, Peoples R China
[4] Holly Lab Shanghai, Shanghai 200233, Peoples R China
来源：
CANCER LETTERS | 2013年 / 337卷 / 02期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
Zinc finger protein X-linked (ZFX); ERK-MAPK; Gastric cancer (GC); SIGNALING PATHWAYS; GENE-EXPRESSION; APOPTOSIS; BAX; PROLIFERATION;
D O I：
10.1016/j.canlet.2013.04.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Zinc finger protein X-linked (ZFX) is a zinc finger transcription factor encoded on the X chromosome. Here, we found that ZFX expression was significantly upregulated in gastric cancer (GC) cell lines and tissues. Knockdown of ZFX induced significant apoptosis and cell cycle arrest in SGC7901 and MGC803 cells. Moreover, we demonstrated for the first time that knockdown of ZFX inhibited gastric cancer cell growth in vitro and in vivo via downregulating the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK-MAPK) pathway. Therefore, ZFX play a prominent role in GC tumorigenicity and may have potential applications in the diagnosis or treatment of GC. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：293 / 300
页数：8
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