Objective: To determine the intrastromal layer of corneal deposits in granular corneal dystrophy (GCD). Design: Investigative case report. Methods: A 32-year-old woman with bilateral decreased vision because of corneal deposits was examined with cross-sectional scans using optical coherence tomography (OCT). Results: Visual acuity was 20/100 OU. Multiple confluent gray-white patches with an irregular shape were seen in the corneal stroma, leading to a diffuse opacification. OCT disclosed multiple hyper-reflective dots in the anterior and deeper stromal layers. Conclusion: When severe corneal opacities obscure the clinical differentiation between anterior and deep infiltrates, OCT may determine the layers of the accumulation and select an appropriate surgical procedure.