Copper-Catalyzed One-Pot Oxidation-Aldol/Henry Reaction of Benzylic Amines to α,β-Unsaturated Methyl Ketone/Nitro Compounds

被引：4

作者：

Liu, Jia ^{[1
,2
]}

Zhu, Xiao-Rui ^{[1
]}

Ren, Jiangmeng ^{[1
,2
]}

Chen, Wei-Dong ^{[2
]}

Zeng, Bu-Bing ^{[1
,2
,3
]}

机构：

[1] E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

SYNLETT | 2013年 / 24卷 / 20期

关键词：

aldol reaction; amines; copper; condensation; oxidation;

D O I：

10.1055/s-0033-1338986

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel one-pot synthesis of ,-unsaturated methyl ketone/nitro compounds from benzylic amines through an oxidation-aldol/Henry reaction is reported. The reaction proceeded well by using MCPBA as oxidant and CuCl(2<bold>)2</bold>H2O as catalyst. A variety of functionalized ,-unsaturated methyl ketone/nitro compounds were assembled in moderate yields by application of this catalytic one-pot reaction.

引用

页码：2740 / 2742

页数：3

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