Renalase in hypertension and kidney disease

被引：80

作者：

Desir, Gary V. ^{[1
,2
]}

Peixoto, Aldo J. ^{[1
,2
]}

机构：

[1] VA Connecticut Healthcare Syst, Med Serv, West Haven, CT 06516 USA

[2] Yale Univ, Sch Med, Nephrol Sect, New Haven, CT USA

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2014年 / 29卷 / 01期

关键词：

renalase; sympathetic nervous system; hypertension; acute kidney injury; cardiovascular disease; BLOOD-PRESSURE; MONOAMINE-OXIDASE; ASSOCIATION; DOPAMINE; EXCRETION; SYSTEM; GENE;

D O I：

10.1093/ndt/gft083

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Renalase, a recently discovered flavoprotein, which is strongly expressed in the kidney and heart, effectively metabolizes catecholamines. It was discovered during the search to identify proteins secreted by the kidney that could help explain the high incidence of cardiovascular disease in patients with chronic kidney disease. Recent advances have led to more detailed knowledge of its biology, structure, enzymatic activity, mechanisms of action, associations with human disease states and potential therapeutic value. In this study, we review these advances with a focus on hypertension and kidney disease.

引用

页码：22 / 28

页数：7

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