JAK2V617F mutational status and allele burden have little influence on clinical phenotype and prognosis in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis

被引:33
作者
Guglielmelli, Paola [1 ,2 ]
Barosi, Giovanni [3 ]
Pieri, Lisa [1 ,2 ]
Antonioli, Elisabetta [1 ,2 ]
Bosi, Alberto [1 ,2 ]
Vannucchi, Alessandro M. [1 ,2 ]
机构
[1] Univ Florence, Dipartimento Area Crit, Unita Funz Ematol, I-50134 Florence, Italy
[2] Ist Toscano Tumori, Florence, Italy
[3] Fdn IRCCS Policlin San Matteo, Ctr Studio Mielofibrosi, Unita Epidemiol Clin, Pavia, Italy
来源
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2009年 / 94卷 / 01期
关键词
myelofibrosis; JAK2V647F mutation; polycythemia vera; essential thrombocythemia; MYELOPROLIFERATIVE DISORDERS; V617F MUTATION; JAK2; CRITERIA;
D O I
10.3324/haematol.13721
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:144 / 146
页数:3
相关论文
共 13 条
  • [1] Influence of JAK2V617F allele burden on phenotype in essential thrombocythemia
    Antonioli, Elisabetta
    Guglielmelli, Paola
    Poli, Giada
    Bogani, Costanza
    Pancrazzi, Alessandro
    Longo, Giovanni
    Ponziani, Vanessa
    Tozzi, Lorenzo
    Pieri, Lisa
    Santini, Valeria
    Bosi, Alberto
    Vannucchi, Alessandro M.
    [J]. HAEMATOLOGICA, 2007, 93 (01) : 41 - 48
  • [2] Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a consensus statement from the international working group for myelofibrosis research and treatment
    Barosi, G.
    Mesa, R. A.
    Thiele, J.
    Cervantes, F.
    Campbell, P. J.
    Verstovsek, S.
    Dupriez, B.
    Levine, R. L.
    Passamonti, F.
    Gotlib, J.
    Reilly, J. T.
    Vannucchi, A. M.
    Hanson, C. A.
    Solberg, L. A.
    Orazi, A.
    Tefferi, A.
    [J]. LEUKEMIA, 2008, 22 (02) : 437 - 438
  • [3] JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis
    Barosi, Giovanni
    Bergamaschi, Gaetano
    Marchetti, Monia
    Vannucchi, Alessandro M.
    Guglielmelli, Paola
    Antonioli, Elisabetta
    Massa, Margherita
    Rosti, Vittorio
    Campanelli, Rita
    Villani, Laura
    Viarengo, Gianluca
    Gattoni, Elisabetta
    Gerli, Giancarla
    Specchia, Giorgina
    Tinelli, Carmine
    Rambaldi, Alessandro
    Barbui, Tiziano
    [J]. BLOOD, 2007, 110 (12) : 4030 - 4036
  • [4] MPL mutations in myeloproliferative disorders:: analysis of the PT-1 cohort
    Beer, Philip A.
    Campbell, Peter J.
    Scott, Linda M.
    Bench, Anthony J.
    Erber, Wendy N.
    Bareford, David
    Wilkins, Bridget S.
    Reilly, John T.
    Hasselbalch, Hans C.
    Bowman, Richard
    Wheatley, Keith
    Buck, Georgina
    Harrison, Claire N.
    Green, Anthony R.
    [J]. BLOOD, 2008, 112 (01) : 141 - 149
  • [5] V617F mutation in JAK2 is associated idiopathic myelofibrosis
    Campbell, PJ
    Griesshammer, M
    Döhner, K
    Döhner, H
    Kusec, R
    Hasselbalch, HC
    Larsen, TS
    Pallisgaard, N
    Giraudier, S
    Le Bousse-Kerdilès, MC
    Desterke, C
    Guerton, B
    Dupriez, B
    Bordessoule, D
    Fenaux, P
    Kiladjian, JJ
    Viallard, JF
    Brière, J
    Harrison, CN
    Green, AR
    Reilly, JT
    [J]. BLOOD, 2006, 107 (05) : 2098 - 2100
  • [6] Anaemia characterises patients with myelofibrosis harbouring MplW515L/K mutation
    Guglielmelli, Paola
    Pancrazzi, Alessandro
    Bergamaschi, Gaetano
    Rosti, Vittorio
    Villani, Laura
    Antonioli, Elisabetta
    Bosi, Alberto
    Barosi, Giovanni
    Vannucchi, Alessandro M.
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2007, 137 (03) : 244 - 247
  • [7] Relation between JAK2 (V617F) mutation status, granulocyte activation, and constitutive mobilization of CD34+ cells into peripheral blood in myeloproliferative disorders
    Passamonti, F
    Rumi, E
    Pietra, D
    Della Porta, MG
    Boveri, E
    Pascutto, C
    Vanelli, L
    Arcaini, L
    Burcheri, S
    Malcovati, L
    Lazzarino, M
    Cazzola, M
    [J]. BLOOD, 2006, 107 (09) : 3676 - 3682
  • [8] Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival
    Tefferi, A.
    Lasho, T. L.
    Huang, J.
    Finke, C.
    Mesa, R. A.
    Li, C. Y.
    Wu, W.
    Hanson, C. A.
    Pardanani, A.
    [J]. LEUKEMIA, 2008, 22 (04) : 756 - 761
  • [9] The JAK2V617F tyrosine kinase mutation in myelofibrosis with myeloid metaplasia:: lineage specificity and clinical correlates
    Tefferi, A
    Lasho, TL
    Schwager, SM
    Steensma, DP
    Mesa, RA
    Li, CY
    Wadleigh, M
    Gilliland, DG
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2005, 131 (03) : 320 - 328
  • [10] Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelotibrosis: recommendations from an ad hoc international expert panel
    Tefferi, Ayalew
    Thiele, Juergen
    Orazi, Attilio
    Kvasnicka, Hans Michael
    Barbui, Tiziano
    Hanson, Curtis A.
    Barosi, Giovanni
    Verstovsek, Srdan
    Birgegard, Gunnar
    Mesa, Ruben
    Reilly, John T.
    Gisslinger, Heinz
    Vannucchi, Alessandro M.
    Cervantes, Francisco
    Finazzi, Guido
    Hoffman, Ronald
    Gilliland, D. Gary
    Bloomfield, Clara D.
    Vardiman, James W.
    [J]. BLOOD, 2007, 110 (04) : 1092 - 1097