Thin-layer chromatography in medicinal chemistry

被引：11

作者：

Segan, Sandra ^{[1
]}

Opsenica, Dejan ^{[1
]}

Milojkovic-Opsenica, Dusanka ^{[2
]}

机构：

[1] Univ Belgrade, Dept Chem, ICTM, Belgrade, Serbia

[2] Univ Belgrade, Fac Chem, Studentski Trg 12-16,POB 51, Belgrade 11158, Serbia

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2019年 / 42卷 / 9-10期

关键词：

ADMET parameters; bioautography; lipophilicity; TLC in drug development; INDICATING HPTLC METHOD; ARTIFICIAL MEMBRANE CHROMATOGRAPHY; PERFORMANCE LIQUID-CHROMATOGRAPHY; BIOLOGICAL-ACTIVITY; RP-TLC; PHARMACEUTICAL FORMULATION; VALIDATED HPTLC; RETENTION DATA; BULK POWDER; LIPOPHILICITY;

D O I：

10.1080/10826076.2019.1585615

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Among widely used chromatographic methods modern thin-layer chromatography is not only the simplest to perform but is also considered as respectable analytical method in various phases of drug discovery and development processes such as monitoring of synthesis, identification of bioactive substances from various natural sources and their isolation and purification, determination of lipophilicity and other physico-chemical parameters, quantitative structure-activity relationship studies, bioautography, as well as qualitative and quantitative analysis of drugs and their metabolites. An overview of recently published papers dealing with application of thin-layer chromatography in medicinal chemistry is presented.

引用

页码：238 / 248

页数：11

共 112 条

[1] Probing into the Molecular Requirements for Antioxidant Activity in Plant Phenolic Compounds Utilizing a Combined Strategy of PCA and ANN [J].