Germline Energetics, Aging, and Female Infertility

被引：154

作者：

Tilly, Jonathan L. ^{[1
,2
]}

Sinclair, David A. ^{[3
,4
,5
]}

机构：

[1] Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA 02114 USA

[2] Harvard Univ, Dept Obstet Gynecol & Reprod Biol, Sch Med, Boston, MA 02115 USA

[3] Harvard Univ, Glenn Labs Biol Mech Aging, Sch Med, Boston, MA 02115 USA

[4] Harvard Univ, Dept Genet, Sch Med, Boston, MA 02115 USA

[5] Univ New S Wales, Sydney, NSW 2052, Australia

来源：

CELL METABOLISM | 2013年 / 17卷 / 06期

关键词：

ASSISTED REPRODUCTIVE TECHNOLOGIES; MUSCLE MITOCHONDRIAL-FUNCTION; CALORIE RESTRICTION; STEM-CELLS; MATERNAL AGE; LIFE-SPAN; HUMAN OOCYTES; IN-VITRO; CHROMOSOME-ABNORMALITIES; DIETARY RESTRICTION;

D O I：

10.1016/j.cmet.2013.05.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail earlier than most other organs. Growing interest in ovarian function is being driven by recent evidence that mammalian females routinely generate new oocytes during adult life through the activity of germline stem cells. In this perspective, we overview the female reproductive system as a powerful and clinically relevant model to understand links between aging and metabolism, and we discuss new concepts for how oocytes and their precursor cells might be altered metabolically to sustain or increase ovarian function and fertility in women.

引用

页码：838 / 850

页数：13

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