A [3+3] annelation approach to tetrahydropyridines

被引：44
作者：
Pattenden, Lisa C.
Wybrow, Robert A. J.
Smith, Stephen A.
Harrity, Joseph P. A.
机构：
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[2] GlaxoSmithKline Res & Dev Ltd, Stevenage SG1 2NY, Herts, England
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 14期
关键词：
D O I：
10.1021/ol0610789
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A stepwise [3+3] annelation sequence to tetrahydropyridines via addition of the BUchi Grignard to aziridines has been developed. These intermediates can be further functionalized with good regio- and stereocontrol and this methodology has been employed in the stereoselective formal synthesis of (-)-dihydropinidine.
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页码：3089 / 3091
页数：3
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