共 45 条
Evaluation of reactive Epstein-Barr Virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS)
被引:15
作者:
Ramroodi, Nourollah
[1
]
Niazi, Abbas Ali
[2
]
Sanadgol, Nima
[3
,4
]
Ganjali, Zohre
[3
]
Sarabandi, Vida
[3
]
机构:
[1] Zahedan Univ Med Sci, Dept Neurol, Zahedan, Iran
[2] Zahedan Univ Med Sci, Dept Pathol, Zahedan, Iran
[3] Zabol Univ, Fac Sci, Dept Biol, Zabol, Iran
[4] Univ Tehran Med Sci, Cellular & Mol Res Ctr, Tehran, Iran
关键词:
EBV;
MS;
Reactivation;
qPCR;
ELISA;
PATHOGENESIS;
INFECTION;
RISK;
DISEASE;
ASSOCIATION;
ANTIBODIES;
BLOOD;
CELLS;
D O I:
10.1016/j.bjid.2012.09.008
中图分类号:
R51 [传染病];
学科分类号:
100401 ;
摘要:
Objectives: Epstein-Barr virus has been recently associated with the onset of multiple sclerosis, yet understanding how it elicits autoimmunity remains elusive. We investigated the relation between Epstein-Barr virus reactivation and disease development in different subtypes of multiple sclerosis. Methods: In the present research, we have determined the Epstein-Barr virus-DNA load by quantitative real-time polymerase chain reaction and Epstein-Barr virus antibody levels by EIA technique in both multiple sclerosis patients (n = 78) and healthy controls (n = 123). Results: Our results demonstrated increased titer of both anti-Epstein-Barr virus-IgG and IgM antibodies in patients (91.02% vs 82.11% in controls, p < 0.001 and 14.1% vs 4.06% in controls, p < 0.001, respectively). Overall, Epstein-Barr virus reactivation was found in 68.75% of subtypes of multiple sclerosis, 4.54% of multiple sclerosis primary subtype, and in only 3.25% of healthy control subjects. Moreover, in samples of patients with disease relapse (exacerbation) cell free viral DNA was elevated in contrast to other patients (p < 0.001). Conclusions: These findings provide further support for the detrimental effects of Epstein-Barr virus in the reactivation of multiple sclerosis attacks. (C) 2013 Elsevier Editora Ltda. All rights reserved.
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页码:156 / 163
页数:8
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