Empirical antibacterial drug discovery - Foundation in natural products

被引：168

作者：

Singh, SB ^{[1
]}

Barrett, JF ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Nat Prod Chem, Rahway, NJ 07065 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2006年 / 71卷 / 07期

关键词：

natural products; antibiotics; fermentation; mechanism-of-action; new targets; empiric screening;

D O I：

10.1016/j.bcp.2005.12.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Natural products have been a rich source in providing leads for the development of drugs for the treatment of bacterial infections. However, beyond the discovery of the natural product, thienamycin and the synthetic lead, oxazolidinone in the 1970s, there has been a dearth of new compounds. This commentary provides an overview of current antibiotic leads and their mechanism of action, and highlights tools that can be applied to the discovery of new antibiotics. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1006 / 1015

页数：10

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