Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma

被引：33

作者：

Yan, Ting-Ting ^{[1
]}

Fu, Xue-Liang ^{[2
]}

Li, Jiao ^{[2
]}

Bian, Ying-Nan ^{[3
]}

Liu, De-Jun ^{[2
]}

Hua, Rong ^{[2
]}

Ren, Lin-Lin ^{[1
]}

Li, Cheng-Tao ^{[3
]}

Sun, Yong-Wei ^{[2
]}

Chen, Hao-Yan ^{[1
]}

Fang, Jing-Yuan ^{[1
]}

Hong, Jie ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, State Key Lab Oncogene & Related Genes,Sch Med, Key Lab Gastroenterol & Hepatol,Renji Hosp,Minist, Div Gastroenterol & Hepatol,Shanghai Inst Digest, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Biliary Pancreat Surg, Shanghai 200030, Peoples R China

[3] Minist Justice, Shanghai Key Lab Forens Med, Inst Forens Sci, Shanghai, Peoples R China

来源：

ONCOTARGET | 2015年 / 6卷 / 35期

基金：

国家高技术研究发展计划(863计划);

关键词：

pancreatic cancer; RPL15; metastasis; biomarker; PDAC; Pathology Section; RIBOSOMAL-PROTEIN L15; EPITHELIAL-MESENCHYMAL TRANSITIONS; CELL-PROLIFERATION; CANCER CELLS; IDENTIFICATION; GENES; CHEMOTHERAPY; CONTRIBUTES; APOPTOSIS; CLONING;

D O I：

10.18632/oncotarget.5939

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Early diagnosis and treatment in pancreatic ductal adenocarcinoma (PDAC) is still a challenge worldwide. The poor survival of PDAC patients mainly due to early metastasis when first diagnosed and lack of prognostic biomarker. Ribosomal protein L15 (RPL15), an RNA-binding protein, is a component of ribosomal 60S subunit. It was reported that RPL15 is dysregulated in various type of cancers. However, little is known about the role of RPL15 in PDAC carcinogenesis and progression. Herein, we clarified RPL15 expression status may serve as an independent prognostic biomarker in three independent PDAC patient cohorts. We found that RPL15 was dramatically decreased in PDAC tissues and cell lines. The high expression of RPL15 was inversely correlated with TNM stage, histological differentiation, T classification and vascular invasion. Low expression of RPL15 was significantly associated with poor overall survival of PDAC patients. Furthermore, we demonstrated that the reduction of RPL15 may promote invasion ability of pancreatic cell by inducing EMT process. In conclusion, decreased RPL15 expression is associated with invasiveness of PDAC cells, and RPL15 expression status may serve as a reliable prognostic biomarker in PDAC patients.

引用

页码：37028 / 37042

页数：15

共 35 条

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