FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis

被引：10

作者：

Berg, DT

Gerlitz, B

Sharma, GR

Richardson, MA

Stephens, EJ

Grubbs, RL

Holmes, KC

Fynboe, K

Montani, D

Cramer, MS

Engle, SD

Jakubowski, JA

Heuer, JG

Grinnell, BW ^{[1
]}

机构：

[1] Lilly Corp Ctr, Lilly Res Labs, Biotechnol Discovery Res, Indianapolis, IN 46285 USA

[2] Lilly Corp Ctr, Lilly Res Labs, Pharmacol Core, Indianapolis, IN 46285 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2006年 / 13卷 / 03期

关键词：

D O I：

10.1128/CVI.13.3.426-432.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated hepatocytes demonstrated regulation of both its cofactor HNF6 and PC. Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis.

引用

收藏

页码：426 / 432

页数：7

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