Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes

被引：80
作者：
Sag, Can M. [1 ,2 ]
Wagner, Stefan [2 ]
Maier, Lars S. [2 ]
机构：
[1] Kings Coll London, James Black Ctr, Div Cardiovasc, London, England
[2] Univ Gottingen, Deutsch Zentrum Herzkreislaufforsch, Abt Kardiol & Pneumol, Herzzentrum, D-37075 Gottingen, Germany
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2013年 / 63卷
关键词：
Sodium; Calcium; CaMKII; Ca handling; SR Ca leak; Late Na current; Exciation-contraction; Coupling; ROS; PROTEIN-KINASE-C; XANTHINE OXIDOREDUCTASE INHIBITION; MEDIATED LIPID-PEROXIDATION; FAILING HUMAN HEARTS; SARCOPLASMIC-RETICULUM; NITRIC-OXIDE; RYANODINE RECEPTOR; FREE-RADICALS; OXIDATIVE STRESS; NADPH OXIDASE;
D O I：
10.1016/j.freeradbiomed.2013.05.035
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review article we give an overview of current knowledge with respect to redox-sensitive alterations in Na+ and Ca2+ handling in the heart. In particular, we focus on redox-activated protein kinases including cAMP-dependent protein kinase A (PKA), protein kinase C (PKC), and Ca/calmodulin-dependent protein kinase II (CaMKII), as well as on redox-regulated downstream targets such as Na+ and Ca2+ transporters and channels. We highlight the pathological and physiological relevance of reactive oxygen species and some of its sources (such as NADPH oxidases, NOXes) for excitation-contraction coupling (ECC). A short outlook with respect to the clinical relevance of redox-dependent Na+ and Ca2+ imbalance will be given. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：338 / 349
页数：12
相关论文
共 169 条
  • [11] Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
    Barouch, LA
    Harrison, RW
    Skaf, MW
    Rosas, GO
    Cappola, TP
    Kobeissi, ZA
    Hobai, IA
    Lemmon, CA
    Burnett, AL
    O'Rourke, B
    Rodriguez, ER
    Huang, PL
    Lima, JAC
    Berkowitz, DE
    Hare, JM
    [J]. NATURE, 2002, 416 (6878) : 337 - 340
  • [12] The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    Bedard, Karen
    Krause, Karl-Heinz
    [J]. PHYSIOLOGICAL REVIEWS, 2007, 87 (01) : 245 - 313
  • [13] The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function
    Belevych, Andriy E.
    Terentyev, Dmitry
    Terentyeva, Radmila
    Nishijima, Yoshinori
    Sridhar, Arun
    Hamlin, Robert L.
    Carnes, Cynthia A.
    Gyoerke, Sandor
    [J]. CARDIOVASCULAR RESEARCH, 2011, 90 (03) : 493 - 502
  • [14] Augmented protein kinase C-α-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure
    Belin, Rashad J.
    Sumandea, Marius P.
    Allen, Edward J.
    Schoenfelt, Kelly
    Wang, Helen
    Solaro, R. John
    de Tombe, Pieter P.
    [J]. CIRCULATION RESEARCH, 2007, 101 (02) : 195 - 204
  • [15] Role of myocardial neuronal nitric oxide synthase-derived nitric oxide in β-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure in rat
    Bendall, JK
    Damy, T
    Ratajczak, P
    Loyer, X
    Monceau, V
    Marty, I
    Milliez, P
    Robidel, E
    Marotte, F
    Samuel, JL
    Heymes, C
    [J]. CIRCULATION, 2004, 110 (16) : 2368 - 2375
  • [16] Calcium cycling and signaling in cardiac myocytes
    Bers, Donald M.
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 2008, 70 : 23 - 49
  • [17] Regulation of Ca2+ and Na+ in normal and failing cardiac myocytes
    Bers, Donald M.
    Despa, Sanda
    Bossuyt, Julie
    [J]. INTERACTIVE AND INTEGRATIVE CARDIOLOGY, 2006, 1080 : 165 - 177
  • [18] Facilitation of murine cardiac L-type Cav1.2 channel is modulated by Calmodulin kinase II-dependent phosphorylation of S1512 and S1570
    Blaich, Anne
    Welling, Andrea
    Fischer, Stefanie
    Wegener, Joerg Werner
    Koestner, Katharina
    Hofmann, Franz
    Moosmang, Sven
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (22) : 10285 - 10289
  • [19] CHARACTERIZATION OF PROTEIN-KINASE-C ISOTYPE EXPRESSION IN ADULT-RAT HEART - PROTEIN-KINASE C-EPSILON IS A MAJOR ISOTYPE PRESENT, AND IT IS ACTIVATED BY PHORBOL ESTERS, EPINEPHRINE, AND ENDOTHELIN
    BOGOYEVITCH, MA
    PARKER, PJ
    SUGDEN, PH
    [J]. CIRCULATION RESEARCH, 1993, 72 (04) : 757 - 767
  • [20] MODIFICATION OF THE GATING OF THE CARDIAC SARCOPLASMIC-RETICULUM CA2+-RELEASE CHANNEL BY H2O2 AND DITHIOTHREITOL
    BORASO, A
    WILLIAMS, AJ
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 267 (03): : H1010 - H1016
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