Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes

被引：80
作者：
Sag, Can M. [1 ,2 ]
Wagner, Stefan [2 ]
Maier, Lars S. [2 ]
机构：
[1] Kings Coll London, James Black Ctr, Div Cardiovasc, London, England
[2] Univ Gottingen, Deutsch Zentrum Herzkreislaufforsch, Abt Kardiol & Pneumol, Herzzentrum, D-37075 Gottingen, Germany
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2013年 / 63卷
关键词：
Sodium; Calcium; CaMKII; Ca handling; SR Ca leak; Late Na current; Exciation-contraction; Coupling; ROS; PROTEIN-KINASE-C; XANTHINE OXIDOREDUCTASE INHIBITION; MEDIATED LIPID-PEROXIDATION; FAILING HUMAN HEARTS; SARCOPLASMIC-RETICULUM; NITRIC-OXIDE; RYANODINE RECEPTOR; FREE-RADICALS; OXIDATIVE STRESS; NADPH OXIDASE;
D O I：
10.1016/j.freeradbiomed.2013.05.035
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review article we give an overview of current knowledge with respect to redox-sensitive alterations in Na+ and Ca2+ handling in the heart. In particular, we focus on redox-activated protein kinases including cAMP-dependent protein kinase A (PKA), protein kinase C (PKC), and Ca/calmodulin-dependent protein kinase II (CaMKII), as well as on redox-regulated downstream targets such as Na+ and Ca2+ transporters and channels. We highlight the pathological and physiological relevance of reactive oxygen species and some of its sources (such as NADPH oxidases, NOXes) for excitation-contraction coupling (ECC). A short outlook with respect to the clinical relevance of redox-dependent Na+ and Ca2+ imbalance will be given. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：338 / 349
页数：12
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