Bioactive Glasses: Sprouting Angiogenesis in Tissue Engineering

被引：274

作者：

Kargozar, Saeid ^{[1
]}

Baino, Francesco ^{[2
]}

Hamzehlou, Sepideh ^{[3
,4
]}

Hill, Robert G. ^{[5
]}

Mozafari, Masoud ^{[6
,7
,8
]}

机构：

[1] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mashhad, Iran

[2] Politecn Torino, Inst Mat Phys & Engn, Dept Appl Sci & Technol DISAT, Turin, Italy

[3] Univ Tehran Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[4] USERN, Med Genet Network MeGeNe, Tehran, Iran

[5] Queen Mary Univ London, Barts & London Sch Med & Dent, Unit Dent Phys Sci, Mile End Rd, London E1 4NS, England

[6] MERC, Bioengn Res Grp, Nanotechnol & Adv Mat Dept, POB 14155-4777, Tehran, Iran

[7] IUMS, Cellular & Mol Res Ctr, Tehran, Iran

[8] IUMS, Fac Adv Technol Med, Dept Tissue Engn & Regenerat Med, Tehran, Iran

来源：

TRENDS IN BIOTECHNOLOGY | 2018年 / 36卷 / 04期

关键词：

INORGANIC TRACE-ELEMENTS; BONE REGENERATION; STIMULATE ANGIOGENESIS; ENDOTHELIAL-CELLS; FUNCTIONAL-ROLE; TUBE FORMATION; STEM-CELLS; SCAFFOLDS; VASCULARIZATION; OSTEOGENESIS;

D O I：

10.1016/j.tibtech.2017.12.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The biggest strategic challenge for tissue engineering is the development of efficient vascularized networks in engineered tissues and organs. Bioactive glasses (BGs) are potent biomaterials for inducing angiogenesis in hard and soft tissue engineering applications. Because tissue-healing processes strongly depend on angiogenesis, recent interest in BGs has increased dramatically. BGs with improved angiogenetic properties can be developed by adding a range of metallic ions (e.g., Cu2+, Co2+) into their structure, but further development of BGs with improved angiogenic activity is required, and many crucial questions remain to be answered. We introduce here the salient features, the hurdles that must be overcome, and the hopes and constraints for the development of this approach.

引用

页码：430 / 444

页数：15

共 109 条

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