Oxidised LDL/LDL-cholesterol ratio and coronary artery calcification in haemodialysis patients

被引：13

作者：

Asamiya, Y. ^{[1
]}

Yajima, A. ^{[2
]}

Tsuruta, Y. ^{[1
]}

Otsubo, S. ^{[3
]}

Nitta, K. ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Kidney Ctr, Dept Med, Shinjuku Ku, Tokyo 1628666, Japan

[2] Towa Hosp, Dept Nephrol, Adachi Ku, Tokyo 1200003, Japan

[3] Sangenjaya Hosp, Dept Blood Purificat, Setagaya Ku, Tokyo 1540024, Japan

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2013年 / 23卷 / 07期

关键词：

Oxidised LDL; MDA-LDL; Coronary artery calcification; Haemodialysis; LDL-cholesterol; LOW-DENSITY-LIPOPROTEIN; MALONDIALDEHYDE-MODIFIED LDL; CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE; VASCULAR CALCIFICATION; CARDIOVASCULAR MORTALITY; ASSOCIATION; UREMIA; SERUM; RISK;

D O I：

10.1016/j.numecd.2012.02.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: Serum malondialdehyde-modified low-density lipoprotein (MDA-LDL) and MDA-LDL/LDL-cholesterol (LDL-c) ratio are risk factors for arteriosclerosis and cardiovascular disease (CVD). However, no information is available on these parameters or their associations with coronary artery calcification (CAC) in haemodialysis (HD) patients. Methods and results: Fifty-seven HD patients and 26 control subjects were included in this cross-sectional study. Serum MDA-LDL concentrations and MDA-LDL/LDL-c ratios were examined. HD patients had significantly higher MDA-LDL/LDL-c ratios than the controls (105.1 +/- 27.5 vs. 81.4 +/- 18.9 mU/mg, P < 0.001); however, there was no significant difference in serum MDA-LDL levels between the 2 groups. CAC scores were examined only in HD patients and their possible associations with the clinical/laboratory data were analysed. Analysis of HD patients showed that MDA-LDL/LDL-c ratio has an association with presence of CVD, CAC score, HD duration, MDA-LDL, or haemoglobin A(1C). In addition, the CAC score was positively correlated with serum MDA-LDL level (P = 0.048) and MDA-LDL/LDL-c ratio (P = 0.006). Furthermore, multivariate logistic regression analysis showed that MDA-LDL/LDL-c ratio (beta = 0.04, P = 0.003) and HD duration (beta = 0.16, P = 0.007) were independently associated with CAC score. Conclusion: The MDA-LDL/LDL-c ratio of HD patients was significantly higher than that of non-HD subjects and was independently associated with the CAC score. Therefore, this ratio could be an important risk factor for CAC in HD patients. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：619 / 627

页数：9

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